• Support for healthy discs, ligaments, and tendons.‡
  • Supports cellular function as enzyme cofactor.‡

$21.00 or Original price was: $21.00.Current price is: $18.90. / month

(Subscriptions can be managed in your account and cancelled at any time without penalty.)

SKU 426 Categories ,


Mangaplex™ provides vitamins, minerals, botanicals, and other nutrients to support the health and healing of discs, ligaments, tendons, and joints.‡

Manganese is a part of the antioxidant enzyme superoxide dismutase (SOD), which is one of the most important antioxidants in your body.  Due to its role as part of the powerful antioxidant superoxide dismutase (SOD), manganese supports healthy levels of inflammation.‡



Warning:  If you are pregnant or lactating woman, have any health conditions, or are taking any medication, make sure to consult your healthcare provider prior to use.

‡ These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure or prevent any disease.



One capsule daily.


60 Capsules


Strause L, Saltman P, Smith KT, Bracker M, Andon MB. Spinal bone loss in postmenopausal women supplemented with calcium and trace minerals. J Nutr. 1994 Jul;124(7):1060-4. doi: 10.1093/jn/124.7.1060. PMID: 8027856.

Robbins D, Zhao Y. Manganese superoxide dismutase in cancer prevention. Antioxid Redox Signal. 2014 Apr 1;20(10):1628-45. doi: 10.1089/ars.2013.5297. Epub 2013 Jul 18. PMID: 23706068; PMCID: PMC3942707.

Yasui K, Baba A. Therapeutic potential of superoxide dismutase (SOD) for resolution of inflammation. Inflamm Res. 2006 Sep;55(9):359-63. doi: 10.1007/s00011-006-5195-y. PMID: 17122956.

Leffler CT, Philippi AF, Leffler SG, Mosure JC, Kim PD. Glucosamine, chondroitin, and manganese ascorbate for degenerative joint disease of the knee or low back: a randomized, double-blind, placebo-controlled pilot study. Mil Med. 1999 Feb;164(2):85-91. PMID: 10050562.

Das A Jr, Hammad TA. Efficacy of a combination of FCHG49 glucosamine hydrochloride, TRH122 low molecular weight sodium chondroitin sulfate and manganese ascorbate in the management of knee osteoarthritis. Osteoarthritis Cartilage. 2000 Sep;8(5):343-50. doi: 10.1053/joca.1999.0308. PMID: 10966840.

Chen P, Bornhorst J, Aschner M. Manganese metabolism in humans. Front Biosci (Landmark Ed). 2018 Mar 1;23:1655-1679. doi: 10.2741/4665. PMID: 29293455.

Ziegler UE, Schmidt K, Keller HP, Thiede A. Behandlung chronischer Wunden mit einer Kalzium-Zink-Mangan-Alginatauflage [Treatment of chronic wounds with an alginate dressing containing calcium zinc and manganese]. Fortschr Med Orig. 2003;121(1):19-26. German. PMID: 15117065.

Li C, Zhou HM. The role of manganese superoxide dismutase in inflammation defense. Enzyme Res. 2011;2011:387176. doi: 10.4061/2011/387176. Epub 2011 Oct 3. PMID: 21977313; PMCID: PMC3185262.